POGIL and many other communities of like-minded people in higher education have been focused for many years on improving teaching and learning in undergraduate STEM courses. These approaches commonly seek to engage faculty in applying student-centered “active” learning approaches that research has shown to improve students’ learning and persistence in STEM, and to close gaps for students who have been traditionally underserved and thus underrepresented in STEM fields. I will review some highlights from the 2019 Levers for Change report, sponsored by AAAS, which offers a snapshot of the current state of progress in changing STEM instruction toward research-based instructional strategies. I will summarize what we know about the uptake of research-based instruction, feature some levers for change that are relevant to POGIL’s past and current work, and pose some challenges as food for thought for the future.